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目的:观察灯盏细辛注射液(EBI)对大鼠急性心肌梗塞(AMI)后肿瘤坏死因子(TNF-α)及纤溶酶原激活物抑制剂1(PAI-1)、组织纤维蛋白溶酶原激活剂(tPA)的影响。方法:通过结扎大鼠左冠状动脉前降支形成AMI模型,术后24 h后随机分为对照组和实验组,持续1 w每天分别腹腔注射生理盐水、EBI低、中、高剂量,观察EBI对病鼠左心室舒张末期压(LVEDP),升高颈动脉平均动脉压(MAP)、左室最大收缩压(LVPmax)和左室内压最大上升和下降速率(±dp/dt)、TNF-α含量、tPA及PAI-1表达的影响。结果:EBI能显著抑制病鼠TNF-α及PAI-1表达(P<0.05),刺激tPA表达的升高(P<0.05),LVEDP显著降低(P<0.05),显著升高MAP、LVPmax和±dp/dt(P<0.05),作用与剂量呈正相关。结论:EBI可通过抑制TNF-α的过度表达,调节PAI-1与tPA的平衡,减缓血栓形成,改善AMI后心脏的血流动力学。
Objective: To observe the effects of Erigeron Breviscapus Injection (EBX) on tumor necrosis factor-α (TNF-α) and plasminogen activator inhibitor 1 (PAI-1), tissue plasminogen activator inhibitor- The impact of the original activator (tPA). Methods: AMI model was established by ligation of the left anterior descending coronary artery in rats. After 24 h, rats were randomly divided into control group and experimental group. The rats were injected intraperitoneally with normal saline for 1 w everyday. The EBI was observed at low, middle and high dose. The effects of left ventricular end-diastolic pressure (LVEDP), elevated carotid artery mean arterial pressure (MAP), left ventricular maximum systolic pressure (LVPmax) and maximal rising and falling rates of left ventricular pressure (± dp / dt) Content, tPA and PAI-1 expression. Results: EBI could significantly inhibit the expression of TNF-α and PAI-1 in rats (P <0.05), increase the expression of tPA (P <0.05), significantly reduce the LVEDP (P <0.05) ± dp / dt (P <0.05), and the effect was positively correlated with the dose. Conclusion: EBI can inhibit the over-expression of TNF-α, regulate the balance of PAI-1 and tPA, slow the thrombosis and improve the hemodynamics of the heart after AMI.