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目的分析探讨子宫肌瘤危险因素、发病机制,分析中西医结合治疗的疗效,为子宫肌瘤防治提供借鉴。方法前瞻性研究,选取2014年1月-2015年8月妇科门诊就诊者1264例,分为病例组和对照组进行因素分析,随机对照研究,选取2014年1月-2015年1月妇科门诊确诊的子宫肌瘤患者200例,随机分为对照组和观察组,单纯给予米非司酮和联合宫瘤消胶囊,1个月经周期为1个疗程。结果单因素分析显示,病例组与对照组年龄≥40岁、农村、超重或肥胖、初潮年龄、盆腔疾病、月经紊乱、累计哺乳时间>2年、经期≥7d、有生育史、不良孕产史、母病史、盆腹腔手术史比较差异具有统计学意义(P<0.05);多因素Logistic分析显示以上部分因素成为独立影响因素,差异有统计学意义(P<0.05);对照组退出3例,观察组退出6例;观察组总显效率90.4%高于对照组的46.4%、无效率0.0%低于对照组的14.4%,观察组治疗后最大肌瘤体积低于对照组,差异具有统计学意义(P<0.05);两组均见数例不良反应,减少米非司酮剂量、对症处理后消失。结论子宫肌瘤的发病机制复杂,与多因素有关;中西医结合治疗子宫肌瘤可增进疗效,药物治疗痊愈率低,有必要加强干预。
Objective To analyze and discuss the risk factors and pathogenesis of uterine fibroids, analyze the curative effect of integrated traditional Chinese and western medicine, and provide reference for the prevention and treatment of uterine fibroids. Methods A prospective study was conducted to select 1264 outpatients in the gynecology outpatient department from January 2014 to August 2015. The patients were divided into two groups: the case group and the control group, and the randomized controlled trials were conducted to select the gynecological clinic diagnosis from January 2014 to January 2015 Of uterine fibroids in 200 patients were randomly divided into control group and observation group, simple administration of mifepristone and Miyao capsule, a menstrual cycle for a course of treatment. Results Univariate analysis showed that case group and control group were more than 40 years old, rural, overweight or obese, menarche age, pelvic disease, menstrual disorders, cumulative breastfeeding time> 2 years, menstruation ≥ 7d, fertility history, poor pregnancy and childbirth history (P <0.05). Multivariate logistic analysis showed that some of the above factors were independent influencing factors, the difference was statistically significant (P <0.05); the control group withdrew from three cases, The observation group exited in 6 cases. The total effective rate in observation group was 90.4% higher than 46.4% in control group, and the inefficiency rate was 0.0% lower than that in control group. The maximal fibroid volume in observation group was lower than that in control group Significance (P <0.05); two groups were seen a few cases of adverse reactions, reduce the dose of mifepristone, symptomatic treatment disappeared. Conclusions The pathogenesis of uterine fibroids is complex and related to many factors. Integrative treatment of uterine fibroids can improve the curative effect, and the cure rate of drug therapy is low, so it is necessary to strengthen the intervention.