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目的:观察替勃隆治疗妇女绝经后更年期综合征的疗效及安全性。方法:选取2012年10月—2013年10月在和田地区人民医院进行治疗的84例绝经后更年期综合征患者,采用抽签的方式将84例患者随机分为对照组和治疗组,每组各42例。对照组患者应用尼尔雌醇进行治疗,治疗组患者应用替勃隆进行治疗,比较2组患者的临床治疗效果。结果:治疗组患者的临床症状改善情况、症状痊愈时间、生活质量评分及治疗总费用均明显优于对照组(P<0.05),不良反应发生率明显低于对照组(P<0.05);治疗组患者的高密度脂蛋白胆固醇水平明显高于对照组(P<0.05),但2组患者低密度脂蛋白胆固醇、雌二醇及三酰甘油水平的差异无统计学意义(P>0.05);治疗前后2组患者的乳腺体层与子宫内膜厚度变化比较,差异无统计学意义(P>0.05)。结论:应用替勃隆治疗妇女绝经后更年期综合征效果较好,能改善更年期症状,且不良反应较少,临床应用价值较高。
Objective: To observe the efficacy and safety of tibolone in treating postmenopausal menopausal syndrome in women. Methods: Eighty-four patients with menopausal menopause syndrome treated in the People’s Hospital of Hotan District from October 2012 to October 2013 were enrolled. 84 patients were randomly divided into control group and treatment group with 42 example. Patients in the control group were treated with nilestriol. The patients in the treatment group were treated with tibolone, and the clinical effects of the two groups were compared. Results: The improvement of clinical symptoms, the recovery time of symptoms, the quality of life score and the total cost of treatment in the treatment group were significantly better than those in the control group (P <0.05), and the incidence of adverse reactions was significantly lower than that in the control group (P <0.05) The level of high density lipoprotein cholesterol in the patients was significantly higher than that in the control group (P <0.05). However, there was no significant difference in the levels of LDL cholesterol, estradiol and triglyceride between the two groups (P> 0.05). There was no significant difference in the changes of mammary gland layer and endometrial thickness between the two groups before and after treatment (P> 0.05). Conclusion: The use of tibolone in the treatment of menopausal menopausal syndrome better effect, can improve menopausal symptoms, and fewer adverse reactions, clinical application of higher value.