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低氧性肺动脉高压(hypoxic pulmonary hypertension,HPH)是慢性阻塞性肺病、慢性高原病和新生儿肺病等临床众多心、肺疾病发病的重要的生理环节,其形成机制尚不完全清楚,防治也不十分理想。低氧性肺血管收缩反应(hypoxic pulmonary vaso-constriction,HPV)和肺血管结构重建(pulmonary artery remodeling,PAR)是HPH的两个主要发病环节,而肺动脉平滑肌细胞(pul-monary arterial smooth musclecell,PASMC)内的钙稳态及膜离子通道,尤其是钙通道和钾通道活性的改变在其中又发挥了非常重要的作用。近年来关于κ-阿片肽对HPH的影响机制有一些研究。本文就其研究进展作一综述。
Hypoxic pulmonary hypertension (HPH) is one of the most important physiological factors in the pathogenesis of chronic obstructive pulmonary disease (COPD), chronic mountain sickness and neonatal pulmonary disease. The mechanism of its formation is not completely understood yet. Very ideal. Hypoxic pulmonary vaso-constriction (HPV) and pulmonary artery remodeling (PAR) are the two main pathogenesis of HPH. Pulmonary arterial smooth muscle cells (PASMC) ) And the changes of membrane ion channels, especially calcium channel and potassium channel, play a very important role. In recent years, there are some researches on the mechanism of influence of κ-opioid peptides on HPH. This article reviews its research progress.