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给麻醉狗、大白鼠和兔静脉注射青藤碱盐酸盐后,皆可产生肯定的降压作用.(?)只狗注射青藤碱(1毫克/公斤)后,平均降压面积为-40±3％.应用同量的药物反复注射三种动物都能出现快速耐受现象;以狗最为明显.在位狗心实验中发现青藤碱在降压同时并不抑制心脏,抗组织胺药不能影响其降压效果,对于M-胆碱反应系统并无影响.本药具抗肾上腺素作用和神经节阻断作用,且能抑制多种中枢性加压反射,故其降压机制可能系抗肾上腺素、阻断神经节和中枢作用的结果.
After intravenous injection of sinomenine hydrochloride into anesthetized dogs, rats and rabbits, a positive antihypertensive effect was observed. (?) Only dogs injected sinomenine (1 mg / kg) 40 ± 3% .Three kinds of animals injected with the same amount of drugs can quickly bear the phenomenon of rapid tolerance; the dog was the most obvious dog heart experiments found that sinomenine in the blood pressure does not inhibit the heart, antihistamine Drugs can not affect its antihypertensive effect, for the M-choline reaction system has no effect.The drug anti-adrenergic effects and ganglion block, and can inhibit a variety of central pressure reflex, so the mechanism may be antihypertensive Department of anti-epinephrine, blocking the results of ganglion and central effects.