论文部分内容阅读
西洋参茎叶皂甙(PQS)50,100,200mg/kg~(-1),d~(-1),po连结续12d,能明显降低高脂血症大鼠血清LDL-C含量,显著升高HDL-C及其亚组分HDL_(2-)C的含量,降低TC/HDL-C和LDL-C/HDL-C比值,尤其以100mg/kg剂量组效果更为显著。对TC含量无明显影响。同时 PQS能显著降低高脂血症大鼠肝组织和血清过氧化脂质(LPO),并提高全血和肝组织谷胱甘肽过氧化物酶(GSH-Px)的活性。结果提示:PQS不仅能纠正高脂血症大鼠脂蛋白-胆固醇代谢紊乱,且能增强机体抗脂质过氧化作用,这些效应均有利于拮抗动脉粥样硬化的发生和发展。
Panax ginseng stem and leaf saponin (PQS) 50,100,200 mg/kg~(-1),d~(-1),po connection continued for 12 days, can significantly reduce serum LDL-C levels in hyperlipidemic rats and significantly increase HDL-C The content of HDL_(2-)C and its subcomponents decreased the TC/HDL-C and LDL-C/HDL-C ratios, especially in the 100 mg/kg dose group. No significant effect on TC content. At the same time, PQS can significantly reduce the liver tissue and serum lipid peroxide (LPO) in hyperlipidemic rats, and increase the activity of whole blood and liver glutathione peroxidase (GSH-Px). The results suggest that PQS can not only correct the disorder of lipoprotein-cholesterol metabolism in hyperlipidemic rats, but also enhance the body’s anti-lipid peroxidation. These effects are beneficial to antagonize the occurrence and development of atherosclerosis.