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目的 :探讨粘附分子上皮型钙粘连素 (E- cadherin)和 CD44 v6在人肝细胞癌 (HCC)中表达的意义。 方法 :用免疫组化法检测 6 6例人 HCC组织中 E- cadherin和 CD44 v6的表达。 结果 :人 HCC中 E- cadherin和 CD44 v6表达的阳性率分别为42 .4%和 39.4% ,且 E- cadherin表达与 HCC侵袭转移倾向呈负相关 (P<0 .0 1) ,与患者 5年生存率呈正相关 (P<0 .0 1) ;而CD44 v6表达与 HCC侵袭转移倾向呈正相关 (P <0 .0 1) ,与患者 5年生存率呈负相关 (P <0 .0 5 )。 结论 :E- cadherin和CD44 v6均与肝癌侵袭转移倾向有关 ,检测 E- cadherin和 CD44 v6的表达可以作为判断肝癌预后的参考指标。
Objective: To investigate the expression of adhesion molecules E-cadherin and CD44 v6 in human hepatocellular carcinoma (HCC). Methods: The expressions of E-cadherin and CD44 v6 in 6 HCC tissues were detected by immunohistochemistry. Results: The positive rates of E-cadherin and CD44 v6 expression in human HCC were 42.4% and 39.4%, respectively. The expression of E-cadherin was negatively correlated with the invasion and metastasis of HCC (P <0.01) (P <0.01). The expression of CD44v6 was positively correlated with the invasion and metastasis of HCC (P <0.01), and had a negative correlation with the 5-year survival rate (P <0.05) ). Conclusion: Both E-cadherin and CD44 v6 are associated with the invasion and metastasis of hepatocellular carcinoma. Detecting the expression of E-cadherin and CD44 v6 can be used as a reference index to determine the prognosis of hepatocellular carcinoma.