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目的 :通过对两种癌基因c -erbB -2和rasP2 1与肺癌的相关研究来揭示它们与肺癌的分期、分型之间的关系。方法 :随机选取 80例肺癌标本用免疫组化ABC法进行染色观察阳性表达率。结果 :C -erbB -2在肺癌中总阳性率 (6 3 8% )明显高于rasP2 1(41 3 % ) (P <0 0 5 ) ,同时在小细胞癌和Ⅲ期肺癌中也有较高的阳性率 ,rasP2 1在肺癌中的阳性率高达 75 % ,明显高于其他类型 (P <0 0 5 )。结论 :C -erbB -2可能与肺癌的转归和发展密切相关 ,而rasP2 1则参与不同类型肺癌 (尤其腺癌 )的发生 ,而与肺癌发展无关。
OBJECTIVE: To investigate the relationship between the two oncogenes, c-erbB-2 and rasP2 1, and lung cancer in order to reveal their relationship with the stage and type of lung cancer. Methods: 80 cases of lung cancer specimens were randomly selected for immunohistochemical ABC staining for the positive expression rate. Results: The positive rate of C-erbB-2 in lung cancer was significantly higher than that of rasP2 1 (41.3%) (P <0 05), and also higher in small cell lung cancer and stage III lung cancer The positive rate of rasP21 in lung cancer was as high as 75%, which was significantly higher than other types (P <0.05). Conclusion: C-erbB-2 may be closely related to the prognosis and development of lung cancer, while rasP21 is involved in the development of different types of lung cancer (especially adenocarcinoma), but not with lung cancer.