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目的 :探讨 DNA含量 ,雌、孕激素受体 (ER、PR)与临床病理特性及预后的关系。方法 :DNA含量 ,ER、PR分别采用图像分析技术及免疫组化技术进行检测。结果 :子宫内膜癌组 DNA含量明显高于 (P<0 .0 1)、ER、PR阳性率则低于 (P<0 .0 5 )子宫内膜腺瘤型增生组及正常子宫内膜组。随着子宫内膜癌由高分化到低分化 ,其 DNA含量逐渐增加 ,ER、PR阳性率逐渐减少 (P<0 .0 5 ) ;二倍体的子宫内膜癌 ER、PR阳性率高 ,预后较好 ,异倍体则反之 (P<0 .0 1)。结论 :子宫内膜癌细胞核 DNA含量与 ER、PR具有相关性。DNA含量、ER、PR与子宫内膜癌的病理分级、临床分期及预后有关
Objective: To investigate the relationship between DNA content, estrogen and progesterone receptor (ER, PR) and clinicopathological features and prognosis. Methods: DNA content, ER, PR were detected by image analysis and immunohistochemistry respectively. Results: The content of DNA in endometrial carcinoma was significantly higher than that in endometrial carcinoma (P <0.01), while the positive rate of ER and PR was lower than that in endometrial adenoma (P <0.05) group. With the endometrial carcinoma from highly differentiated to poorly differentiated, its DNA content gradually increased, ER, PR positive rate decreased (P <0.05); diploid endometrial cancer ER, PR positive rate, Good prognosis, aneuploidy on the contrary (P <0. 01). Conclusion: The nuclear DNA content of endometrial cancer cells is correlated with ER and PR. DNA content, ER, PR and the pathological grade of endometrial cancer, clinical stage and prognosis