论文部分内容阅读
本文对健康人和哮喘患者β-肾上腺素能受体功能,包括肾上腺素能最大结合容量(Bmax)和其反应性,以及肾上腺素注射前后人体反应进行了观察。注意到正常人及病人注射肾上腺素前后在血压、心率、肺功能、血糖、Bmax各项间均有显著差异;且病人及健康人血糖变化与Bmax变化呈线性明显相关(P<0.05)。病情发作严重、短期内应用β受体激动剂较多者,Bmax下降;Bmax与病程关系不大。应用Bmax或注射肾上腺素观察血糖变化,结合患者病情及用药情况,可以推测β受体敏感性,从而指导临床恰当应用β受体激动剂,并为今后如何恢复β受体功能研究打下基础。
In this paper, β-adrenergic receptor functions, including the maximal adrenergic binding capacity (Bmax) and its reactivity, and the human response to epinephrine injection were observed in healthy and asthmatic patients. Significant differences were observed in blood pressure, heart rate, lung function, blood glucose and Bmax before and after injection of epinephrine in both normal subjects and patients. There was a linear correlation between blood glucose and Bmax in patients and healthy people (P <0.05). Severe seizures, short-term use of more β-agonists, Bmax decreased; Bmax and the course of disease is not. Bmax or injection of epinephrine observed blood glucose changes, combined with the patient’s condition and medication, we can speculate β receptor sensitivity, which will guide the clinical application of β receptor agonists, and lay the foundation for the future study on how to restore β receptor function.