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通过特殊的技术将体细胞重编程为具有自我更新能力和多向分化潜能的细胞,这种细胞叫做诱导多能干细胞(induced pluripotent stem cell,iPS cell)。它在形态学以及表观遗传学与胚胎干细胞极为相似。目前,已经成为干细胞和再生医学领域研究的热点。长期职业性锰暴露的人群会出现震颤、肌强直和运动迟缓等类似帕金森病的中毒症状。本文拟从iPS细胞的研究概述、诱导步骤及筛选方法三个方面简介iPS细胞的研究进展并对其在锰中毒治疗中的应用作以展望。
Cells are reprogrammed to have pluripotent stem cells (iPS cells) with self-renewal ability and multidirectional differentiation potential through special techniques. It is very similar in morphology and epigenetics to embryonic stem cells. At present, it has become a hot spot in the field of stem cell and regenerative medicine. Persons exposed to long-term occupational manganese may experience symptoms of Parkinson’s disease similar to tremor, myotonia and bradykinesia. In this paper, iPS cell research overview, induction steps and screening methods from three aspects of iPS cell research progress and its application in the treatment of manganese poisoning prospects.