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BALb/c小鼠66只、Wistar大鼠38只、豚鼠10只和家兔6只分别给予皮下注射醋酸可的松,每周2只.连续给药3周后开始用金胺—酚染色、改良耐酸染色和沙黄—美蓝染色法检查动物粪便中隐孢子虫卵囊.小鼠隐孢子虫卵囊阳性率为71.21%(47/66);大鼠则为34.21%(13/38).小鼠粪便中卵囊数量明显多于大鼠.小鼠粪便中隐孢子虫卵囊可分为大型囊(7.47μ×5.90μ)和小型囊(4.6μ×4.33μ)两种.豚鼠与家兔均未能检出隐孢子虫卵囊.小鼠口服或皮下注射地塞米松均未能诱发隐孢子虫感染.提示小鼠皮下注射醋酸可的松可能是一种较好的建立隐孢子虫感染动物模型的方法
66 BALB / c mice, 38 Wistar rats, 10 guinea pigs and 6 rabbits were injected subcutaneously with cortisone acetate twice a week for 3 weeks, The positive rate of Cryptosporidium oocysts was 71.21% (47/66) in rats and 34.21% (13/38) in rats. The number of oocysts in the feces of mice was significantly more than that of the rats.The Cryptosporidium oocysts in the feces of the mice were divided into two types: large capsule (7.47μ × 5.90μ) and small capsule (4.6μ × 4.33μ) Rabbits were unable to detect Cryptosporidium oocysts mice oral or subcutaneous injection of dexamethasone failed to induce Cryptosporidium infection.It suggests that mice injected subcutaneously with cortisone may be a better Cryptosporidium Methods of Infecting Animal Models