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目的:探讨激素替代治疗(HRT)对更年期综合征妇女绝经相关指标及生活质量的影响。方法:将2005年1月～2011年9月绝经后期妇女60例分为治疗组及对照组各30例,两组均给予饮食及体育锻炼治疗;治疗组口服倍美力0.625 mg/d,28天为1周期,每周期第19～28天加用安宫黄体酮4 mg/d,共3个周期。观察两组患者临床症状缓解情况、各项激素及生化指标的变化情况。结果:治疗组治疗后的临床症状明显改善,雌二醇(E2)、孕激素(P)明显升高,卵泡刺激素(FSH)、黄体生成素(LH)、碱性磷酸酶(AKP)、总胆固醇(TC)及甘油三酯(TG)均明显降低,与治疗前及对照组治疗后比较,差异均有统计学意义(P<0.01,P<0.05)。结论:低剂量雌孕激素联合治疗能显著改善绝经后妇女的激素相关指标水平及临床症状,提高患者的生活质量,值得临床应用推广。
Objective: To investigate the effect of hormone replacement therapy (HRT) on menopausal related indicators and quality of life in climacteric women. Methods: 60 cases of postmenopausal women from January 2005 to September 2011 were divided into treatment group (30 cases) and control group (30 cases). Both groups were treated with diet and physical activity. The treatment group was orally taken orally 0.625 mg / d, 28 Days for the 1 cycle, each cycle from 19 to 28 plus Ann Palace progesterone 4 mg / d, a total of 3 cycles. To observe the clinical symptoms of two groups of patients to alleviate the changes of various hormones and biochemical indicators. Results: After treatment, the clinical symptoms of the treatment group were significantly improved. The levels of estradiol (E2) and progesterone (P) were significantly increased. The levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), alkaline phosphatase Total cholesterol (TC) and triglyceride (TG) were significantly lower than before treatment and control group after treatment, the difference was statistically significant (P <0.01, P <0.05). Conclusion: The combination of low-dose estrogen and progesterone treatment can significantly improve the hormone-related indicators and clinical symptoms in postmenopausal women, improve the quality of life of patients, and worthy of clinical application.