【摘 要】
：
目的:探讨斑蝥酸钠维生素B6注射液联合草酸铂与替加氟持续泵入治疗晚期胃癌的效果.方法:64例晚期胃癌患者分别接受方案A(32例)、方案B(32例)治疗.方案A(A组):替加氟800mg/m2,
【机 构】
：
山东省枣庄矿业集团中心医院肿瘤治疗中心,枣庄,277000
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目的:探讨斑蝥酸钠维生素B6注射液联合草酸铂与替加氟持续泵入治疗晚期胃癌的效果.方法:64例晚期胃癌患者分别接受方案A(32例)、方案B(32例)治疗.方案A(A组):替加氟800mg/m2,CIV(24h),d1-5;LV 200mg/m2,ivgtt(2h),d1～5;L-OHP85mg/m2,ivgtt(2h),d1;斑蝥酸钠维生素B6注射液50mL,d1-28.方案B(B组):替加氟800mg/m2,CIV(24h),d1~5;LV200mg/m2,ivgtt(2h),d1-5;DOHP 85mg/m2,ivgtt(2h),d1;28d为1个周期.结果:方案A:CR7例,PR16例,有效率71.9%;方案B:CR5例,PR16例,有效率65.6%;方案A优于方案B,差异无显著性意义(x2=0.5909,P=0.59).A组患者出现血中白细胞及血小板下降、血清尿素氯及转氨酶升高的数量明显少于B组.A组患者Kamofskv评分明显高于B组患者、精神状态明显好于B组患者、消化道反应明显轻于B组惠者,且A组患者在疼痛缓解、食欲及睡眠改善、体重增加等方面均优于B组(P＜0.05).两种方案的不良反应均易于接受.结论:斑萤酸钠维生素B6注射液联合草酸铂与替加氟持续泵入治疗晚期胃癌具有协同作用,并且具有提高接受化疗患者的生活质量、减轻化疗药物对患者的毒副作用、提高患者对化疗药物的耐受作用.可以作为晚期胃癌安全有效的治疗方案.
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