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研制葛根素纳米晶自稳定Pickering乳液(puerarin nanocrystalline self-stabilized Pickering emulsion,Pu-NSSPE),采用Box-Behnken设计效应面法优化处方以提高其稳定性,研究药物浓度、水相p H和水油体积比对乳液的分层指数、乳液层的药物含量和乳滴粒径变化的影响。结果显示,当葛根素浓度为0.5%,水相p H为9,水油体积比为9时,能得到最稳定的Pu-NSSPE,乳滴粒径为(12.70±1.17)μm,乳液层的药物浓度为(4.49±0.21)g·L-1,室温放置6个月后均无明显变化,稳定性好。采用扫描电镜、激光共聚焦显微镜和荧光倒置显微镜对乳滴结构进行表征,结果显示葛根素纳米晶能吸附于油滴界面形成稳定的球状核-壳结构,这可能是Pu-NSSPE能够长期稳定的微观结构原因。
The puerarin nanocrystalline self-stabilized Pickering emulsion (Pu-NSSPE) was developed. The Box-Behnken design effect surface method was used to optimize the formulation to improve its stability. The drug concentration, pH and water and oil Volume ratio of the delamination index of the emulsion, the drug content of the emulsion layer and the change of the droplet size. The results showed that the most stable Pu-NSSPE was obtained when the concentration of puerarin was 0.5%, the pH of aqueous phase was 9 and the volume ratio of water to oil was 9. The particle size of emulsion droplets was (12.70 ± 1.17) μm. Drug concentration (4.49 ± 0.21) g · L-1, after 6 months at room temperature had no significant change, good stability. The structure of the droplet was characterized by scanning electron microscopy, confocal laser scanning microscopy and fluorescence inverted microscope. The results showed that the puerarin nanorods could adsorb on the oil droplet interface to form a stable spherical core-shell structure, which may be the long-term stability of Pu-NSSPE Microstructure causes.