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波叶大黄多糖(150和300 mg/kg,ig)可明显抑制小鼠肿瘤S180的生长,抑瘤率分别为40%和48%,小鼠ig 100和200 mg/kg,对~(60)Coγ射线辐射损伤有保护作用,死亡率分别降低30%和35%,平均寿命分别增加26%和39%;对环磷酰胺所致小鼠白细胞减少和骨髓微核率增加具有对抗作用,对白细胞下降的对抗率分别为32.6%和51.3%,对骨髓微核率增加的对抗率分别为15.7%和31.6%。小鼠ip 100和200 mg/kg,可明显抑制角叉菜胶引起的足肿胀,抑制率均为78.4%;对CCl_4所致小鼠肝损伤具有保护作用,SGPT分别降低30.4%和32.0%,小鼠ig 100和200 mg/kg,可明显降低正常小鼠血糖,给药7 h后血糖分别降低20.6%和43.8%。小鼠ip100和200 mg/kg,可降低四氧嘧啶所致糖尿病小鼠的血糖,给药后7 h,血糖分别降低53.2%和57.9%。小鼠ip LD_(50)为885.6±128.1mg/kg。
Polyporus umbellatus (150 and 300 mg / kg, ig) significantly inhibited the growth of mouse tumor S180 with 40% and 48% inhibition rates, respectively, and 100 and 200 mg / Co γ-ray radiation injury has a protective effect, the mortality was reduced by 30% and 35%, respectively, the average life expectancy increased by 26% and 39%; cyclophosphamide-induced leukopenia and increased micronucleus rate of bone marrow against white blood cells The decreased confrontation rates were 32.6% and 51.3%, respectively, and the rates of resistance to increased micronuclei were 15.7% and 31.6%, respectively. Mouse ip 100 and 200 mg / kg, can significantly inhibit carrageenan induced foot swelling, the inhibition rate was 78.4%; CCl 4 -induced liver injury in mice, SGPT decreased by 30.4% and 32.0%, respectively, The mouse ig 100 and 200 mg / kg, can significantly reduce the normal mice blood glucose, 7 h after administration of blood glucose were reduced by 20.6% and 43.8%. Mice ip100 and 200 mg / kg, can reduce alloxan-induced diabetic mice blood glucose, 7 h after administration, blood glucose decreased 53.2% and 57.9%. Mouse ip LD_ (50) was 885.6 ± 128.1 mg / kg.