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本实验室曾对丝裂霉素 C(MC)诱发人血培养物的细胞遗传效应进行过观察,在此基础上我们研究了 MC 诱发 CHL 细胞染色体畸变的量效关系。CHL 细胞经不同剂量 MC 处理后,畸变细胞、染色单体断裂(ctb)、单体互换(cte)、易位(t)及总畸变(%)等5项指标随 MC 浓度升高而增加。为进一步检验和描述这5个指标与 MC 浓度的关系,我们用最小二乘法,以 y=c+αx、y=c+αx+βx~2、y=cx~α3个模型,分别对这5个指标进行了回归分析,上述3个模型都可得到具有显著意义的回归参数,根据 F值及相应概率 p 值,p 值从小到大三者次序为:模型1、模型2、模型3。
In our laboratory, the cytogenetic effect of mitomycin C (MC) -induced human blood culture was observed. Based on this, we studied the dose-response relationship of MC-induced chromosomal aberrations in CHL cells. After CHL cells were treated with different doses of MC, five indicators such as aberrant cells, ctb, cte, t and total distortion (%) increased with increasing MC concentration . To further test and describe the relationship between these 5 parameters and MC concentration, we use the least square method to calculate the 5 According to the F value and the corresponding probability p value, the order of p value from small to large is as follows: model 1, model 2, and model 3.