氨氯地平是第二代钙拮抗剂,在化学结构上与硝苯地平和其他1,4双氢吡啶类钙拮抗剂相似;但该药降压作用温和,缓慢持久,半衰期长,可达35～48h,并有较高的生物利用度,所以目前全球已有22个国家用该药治疗高血压病。本文报告作者关于氨氯地平对高血压病的疗效和1次用药后48h的降压效果进行研究的结果。 Amlodipine is a second-generation calcium antagonist that is chemically similar in structure to nifedipine and other 1,4-dihydropyridine calcium antagonists; however, its antihypertensive effect is mild, slow and long lasting, with a long half-life of 35 ~ 48h, and has a higher bioavailability, so the world has 22 countries with the drug for the treatment of hypertension. This article reports the authors’ results on the efficacy of amlodipine in the treatment of hypertension and the antihypertensive effect 48 h after a single dose.