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与抗生素治疗有关的出血症状可能是严重的。Ham报道5例胃肠道外给予氨苄青霉素的患者(其中1例加用卡那霉素)中发现血凝血酶原过少,2例有出血需输血;另2例有少量出血,经用维生素K后,凝血酶原时间正常,出血停止。据报道,15例术后患者竟患维生素K缺乏(凝血酶原时间延长),9例有胃肠出血,除其中1例外,其余均用广谱抗生素和静脉补液。血凝血酶原过少是由于口服维生素K不足和用化疗药物后致使肠内细菌维生素K内源性产生减少所致。58例用胃肠道外羟苄四唑头孢菌素的患者中有10例也
Bleeding symptoms associated with antibiotic therapy can be severe. Ham reported 5 cases of patients receiving parenteral ampicillin (one of them with kanamycin) had too little prothrombin, 2 had bleeding, and the other 2 had a small amount of bleeding. They were treated with vitamin K After prothrombin time was normal, bleeding stopped. It was reported that 15 patients with postoperative patients actually suffering from vitamin K deficiency (prolonged prothrombin time), 9 cases of gastrointestinal bleeding, in addition to one of them, the rest are with broad-spectrum antibiotics and intravenous fluids. Too little prothrombin is due to inadequate oral vitamin K and the use of chemotherapeutic agents resulting in reduced endogenous bacterial vitamin K production. 58 cases of patients with cephalosporin in addition to 10 cases also