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目的 探讨慢性酒精中毒导致大脑损害的程度及其相关因素.方法 采用神经心理测验和颅脑 C T 扫描的方法测量88 例慢性酒精中毒男性患者.结果 88 例患者大脑损伤指数( D Q) 为0?52 ±0?25 ,63 例(72 ％ ) 大脑功能损害程度为中度及其以上,71 例(80 ％ ) 大脑白质萎缩程度为中度及其以上.大脑萎缩度数(5?35 ±1?27) 与每日饮酒最多次数、首次住院戒酒年龄、酒精依赖期饮酒量、酒精依赖年数和 D Q 呈正相关( P＜ 0?05 ~0?01) .结论 慢性酒精中毒会导致广泛性大脑损害.酒精依赖期较长、饮酒量较多、饮酒频率较高 、首次住院戒酒年龄较晚和住院戒酒次数较少等与大脑损害相关.“,”Objective To investigate the extent of the cerebral damage caused by chronic alcoholism and the related factors Methods 88 patients with chronic alcoholism were measured by the Halstead Reitan Battery Neuropsychological Test and brain CT scanning Results The index of the Brain Damage Quotient (DQ) of patients was 0 52±0 25 63 (72%) patients showed a moderate or severe degree of the impairment of cerebral function 71 (80%) patients showed a moderate or severe degree of the atrophy in cerebral white matter The degree of cerebral atrophy was 5 35±1 27,which was positively correlated to the maximum frequency of daily alcohol consumption,the age at the first hospitalization for compulsory abstinence from alcohol,the dosage of alcohol consumption during the period of alcoholic dependence,the years of alcohol dependence,and DQ Conclusions Chronic alcoholism can cause the massive damage to the cerebrum The various factors may be related to cerebral damage such as longer alcohol dependence period,greater consumption of alcohol,higher frequency of drinking,later age at first compulsory abstinence from alcohol,and fewer times of compulsory abstinence from alcohol