论文部分内容阅读
目的探讨新生儿重症监护病房(NICU)极低出生体重儿早期营养状况与后期神经系统发育的关系。方法回顾性选择2013年1月至2014年12月在我院NICU住院且出院后定期在我院高危儿门诊随访的极低出生体重儿,均在校正年龄3个月时评估发育商(DQ),DQ≥130分为优秀,115~129分为中上,85~114分为中等,70~84分为中下,≤69分为智能低下。根据DQ得分将患儿分为神经发育正常组(DQ≥85分)及神经发育异常组(DQ<85分),比较两组患儿住院期间营养状况。结果共纳入125例极低出生体重儿。校正年龄3个月时DQ优秀2例(1.6%),中上3例(2.4%),中等63例(50.4%),中下57例(45.6%);神经发育正常组68例(54.4%),神经发育异常组57例(45.6%)。神经发育正常组生后4、7、14天平均总热卡摄入量[(44.3±8.0)比(37.7±6.8)kcal/kg、(60.4±5.0)比(55.2±6.7)kcal/kg、(92.3±8.0)比(83.1±9.9)kcal/kg]、平均肠内能量所占比例[(9.0±1.8)%比(4.8±1.5)%、(18.6±2.9)%比(10.4±2.6)%、(38.0±2.5)%比(30.4±2.0)%]及生后4、7天平均氨基酸供给量[(1.2±0.2)比(0.9±0.1)g/kg、(1.8±0.1)比(1.6±0.1)g/kg]均高于神经发育异常组,差异有统计学意义(P<0.05)。神经发育正常组体重下降程度较神经发育异常组轻,恢复出生体重时间及达到全肠道喂养时间较神经发育异常组早,两组差异有统计学意义(P<0.05)。结论极低出生体重儿生后早期营养状况与神经系统发育结局相关。
Objective To investigate the relationship between the early nutritional status of very low birth weight neonates and the development of nervous system in neonatal intensive care unit (NICU). Methods Retrospectively select very low birth weight infants who were hospitalized in NICU of our hospital from January 2013 to December 2014 and were regularly followed up in high-risk infants outpatient department in our hospital. , DQ≥130 is divided into excellent, 115 ~ 129 is divided into middle and upper, 85 ~ 114 is divided into medium, 70 ~ 84 is divided into middle and lower, ≤69 is divided into smart low. According to the DQ score, the children were divided into normal group (DQ≥85 points) and abnormal neurological development group (DQ <85 points). The nutritional status of the two groups was compared during hospitalization. Results A total of 125 very low birth weight children were enrolled. DQ was excellent in 2 cases (1.6%), middle and upper 3 cases (2.4%), moderate in 63 (50.4%) and middle and lower 57 cases (45.6% ), Neurodevelopmental group 57 cases (45.6%). The average total caloric intake at 4, 7, and 14 days after the normal group was (44.3 ± 8.0) vs (37.7 ± 6.8) kcal / kg, (60.4 ± 5.0) vs (55.2 ± 6.7) kcal / kg (92 ± 8.0) and (83.1 ± 9.9) kcal / kg, respectively. The average percentage of intestinal energy was (9.0 ± 1.8)% vs (4.8 ± 1.5)%, (18.6 ± 2.9)% vs (10.4 ± 2.6) %, (38.0 ± 2.5)% (30.4 ± 2.0)%], and the mean amino acid supply at 4 and 7 days after birth (1.2 ± 0.2 vs 0.9 ± 0.1 g / kg and 1.8 ± 0.1) 1.6 ± 0.1) g / kg] were higher than those of neurodevelopmental group, the difference was statistically significant (P <0.05). The body weight loss in the normal group was significantly lower than that in the neurodevelopmental group, and the time to restore birth weight and the total gut feeding time were earlier than those in the neurodevelopmental group. There was significant difference between the two groups (P <0.05). Conclusions Early nutritional status of very low birth weight children is related to the development of the nervous system.