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目的利用中草药与153Sm-EDTMP联合治疗骨转移癌,以提高153Sm-EDTMP的疗效和减轻其骨髓抑制的副作用。方法选择经临床和病理确诊为肿瘤的患者54例,随机分为A、B两组进行研究。A组即153Sm-EDTMP治疗组,30例;B组即153Sm-EDTMP+中草药治疗组,24例。153Sm-EDTMP用量为37~74 MBq/kg,中草药选用祛风通络、除湿解毒、益肾补气填精之类。结果A组疼痛缓解和生活质量的改善分别为80%和86.1%,外周血白细胞在用药2周后明显下降(P<0.05),血小板在用药后1个月明显下降(P<0.05);B组疼痛缓解和生活质量的改善分别为91.7%和95.8%,外周血象未见明显改变。结论中草药和153Sm-EDTMP联合治疗骨转移癌具有临床应用价值。
OBJECTIVE To improve the efficacy of 153Sm-EDTMP and to reduce the side effects of its bone marrow suppression by combining Chinese herbs with 153Sm-EDTMP in the treatment of bone metastases. Methods 54 patients diagnosed as tumor by clinic and pathology were randomly divided into A and B groups. A group of 153Sm-EDTMP treatment group, 30 cases; B group 153Sm-EDTMP + Chinese herbal medicine treatment group, 24 cases. 153Sm-EDTMP amount of 37 ~ 74 MBq / kg, Chinese herbal medicine Qufeng meridian, dehumidification detoxification, Kidney Qi fill fine and the like. Results The pain relief and quality of life in group A were improved by 80% and 86.1% respectively. The number of peripheral blood leukocytes decreased significantly after 2 weeks of treatment (P <0.05) and the platelets decreased significantly 1 month after treatment (P <0.05). Group pain relief and improvement of quality of life were 91.7% and 95.8%, no significant changes in peripheral blood. Conclusion Chinese herbal medicine and 153Sm-EDTMP combined treatment of bone metastases have clinical value.