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目的观察高频热疗联合支气管动脉介入化疗治疗局部晚期非小细胞肺癌的疗效。方法60例局部晚期非小细胞肺癌患者随机分为观察组和对照组。观察组(30例)采用高频热疗联合支气管动脉介入化疗,治疗4个周期后评价疗效、生存质量、临床受益率及毒副作用;对照组(30例)采用全身静脉化疗(吉西他滨联合顺铂或紫杉醇联合顺铂),4个周期后评价疗效、生存质量、临床受益率及毒副作用。同时对两组患者进行随访,统计生存率并进行比较。结果观察组与对照组比较,近期疗效、生存质量以及1,2年生存率差异无显著性,临床受益率明显提高,毒副作用明显减少。结论高频热疗联合支气管动脉介入化疗治疗局部晚期非小细胞肺癌,疗效确切,毒副作用减少,可以明显提高临床受益率。
Objective To observe the effect of high-frequency hyperthermia combined with bronchial artery interventional chemotherapy in the treatment of locally advanced non-small cell lung cancer. Methods Sixty patients with locally advanced non-small cell lung cancer were randomly divided into observation group and control group. The observation group (30 cases) received high-frequency hyperthermia combined with bronchial artery interventional chemotherapy. After 4 cycles of treatment, the curative effect, quality of life, clinical benefit rate and side effects were evaluated. In the control group (30 cases), systemic intravenous chemotherapy (gemcitabine combined with cisplatin Or paclitaxel combined with cisplatin), after 4 cycles evaluation of efficacy, quality of life, clinical benefit rates and side effects. At the same time, two groups of patients were followed up, the survival rate was compared and compared. Results Compared with the control group, there was no significant difference between the observation group and the control group in the short-term efficacy, quality of life, and the 1-year and 2-year survival rates. The clinical benefit rate was significantly improved and the side effects were significantly reduced. Conclusion High-frequency hyperthermia combined with bronchial artery interventional chemotherapy in the treatment of locally advanced non-small cell lung cancer has definite curative effect and reduction of toxic and side effects, which can obviously improve the clinical benefit rate.