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目的:探讨静脉联合椎管内注射破伤风抗毒素对重症破伤风的治疗效果。方法:选择2009年1月至2014年1月在我院接受治疗的破伤风患者103例(含新生儿3例),将其分成2组,对照组为52例,观察组为51例。对照组采用破伤风抗毒素静脉滴注治疗,观察组采用静脉联合椎管内注射破伤风抗毒素治疗,对比两组的治疗效果。结果:经过治疗,观察组患者抽搐的次数明显变少,抽搐的时间缩短,住院的时间减少,观察组的死亡率明显低于对照组,P<0.05,有统计学意义。结论:应用静脉联合椎管内注射的方法治疗破伤风,能够减少患者的抽搐次数,缓解其抽搐的症状,降低其死亡率,减少其住院时间,值得临床推广。
Objective: To investigate the therapeutic effect of intravenous combined spinal intratracheal antitoxin on severe tetanus. Methods: A total of 103 tetanus patients (including 3 newborns) treated in our hospital from January 2009 to January 2014 were divided into two groups: control group (n = 52) and observation group (n = 51). The control group was treated with tetanus antitoxin intravenous drip. The observation group was treated with intravenous and intraspinal intratracheal injection of tetanus antitoxin. The therapeutic effect was compared between the two groups. Results: After treatment, the number of convulsions in the observation group was significantly decreased, the twitch time was shortened and the hospitalization time was reduced. The mortality rate in the observation group was significantly lower than that in the control group (P <0.05). Conclusion: Intravenous and intraspinal injection of tetanus for the treatment of tetanus can reduce the number of patients with convulsions, relieve the symptoms of convulsions, reduce their mortality and reduce their hospital stay, worthy of clinical promotion.