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组织型纤溶酶原激活剂(t-PA)能特异地与纤维蛋白结合,并受其激活,为一种高效的溶栓剂。但用于临床时尚有出血倾向。应用分子生物学及蛋白工程技术对t-PA进行改建,为导向溶栓提供了可能。
Tissue-type plasminogen activator (t-PA) specifically binds to fibrin and is activated by it as an efficient thrombolytic agent. But for clinical fashion bleeding tendency. The use of molecular biology and protein engineering technology to t-PA reconstruction, the possibility of guided thrombolysis.