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胆固醇酯转运蛋白(CETP)介导胆固醇酯在高密度脂蛋白和含载脂蛋白B的脂蛋白之间的交换,在胆固醇逆向转运中起重要作用。CETP基因缺陷会引起CETP基因表达障碍,从而影响血脂代谢。大量研究资料表明,CETP基因缺陷与动脉粥样硬化有关。本文重点就CETP基因缺陷与动脉粥样硬化的关系作了综述。
Cholesteryl ester transfer protein (CETP) mediates the exchange of cholesterol esters between high-density lipoproteins and apolipoprotein B-containing lipoproteins and plays an important role in the reverse cholesterol transport. CETP gene defects can cause CETP gene expression disorders, thus affecting blood lipid metabolism. A large number of research data show that CETP gene defects and atherosclerosis related. This review focuses on the relationship between CETP deficiency and atherosclerosis.