Feasibility Evaluation for Selection of Neoadjuvant Chemotherapy before Cytoreduction of Advanced Ov

来源 :Chinese Journal of Clinical Oncology | 被引量 : 0次 | 上传用户:zjbme2010
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Ovarian carcinoma is one of three gynecological neoplasms.It typically develops as an insidious disease,with few warning signs or symptoms,because the ovary is situated at a deep part of the pelvic cavity.Advanced ovarian carcinoma(AOC)is highly malignant,so the prognosis of the patients is poor.Initial debulking surgery,fol owed by chemotherapy, is currently the main therapeutic choice for AOC.During operations,efforts should be made to excise the tumor and minimize the residual lesion,so as to achieve the optimal cytoreduction and improve the prognosis.As a feasible therapeutic regimen for the patients with primary unresectable AOC, neoadjuvant chemotherapy can improve the surgical condition and can increase the optimality of cytoreduction.It is important therefore to evaluate the feasibility of surgical treatment and make a proper selection of the primary treatment plan and neoadjuvant chemotherapy,so as to enhance the optimality of surgery and to avoid unnecessary exploratory laparotomy.At present,methods of feasibility evaluation for optimal cytoreduction of AOC are as fol ows:1)radiography,i.e.,CT,PET and MRI scanning;2)CA-125 value; 3)laparoscopic exploration;4)other tumor markers such as p53.However, any method lacks the ability to cover al the predicting factors influencing the outcome of cytoreduction,and to evaluate the surgery across the board. Searching for new methods and combining two or more procedures to evaluate the feasibility of cytoreduction may increase the optimality,reduce the residual focus,prolong survival time and improve the prognosis.In this study, recent advances in evaluation of the feasibility for optimal cytoreduction and the selection of neoadjuvant chemotherapeutic regimens were reviewed. Ovarian carcinoma is one of three gynecological neoplasms. One typically develops as an insidious disease, with few warning signs or symptoms, because the ovary is situated at a deep part of the pelvic cavity. Advanced ovarian carcinoma (AOC) is highly malignant, so the prognosis of the patient is poor.Initial debulking surgery, fol owed by chemotherapy, is currently the main therapeutic choice for AOC. Operating operations, efforts should be made to excise the tumor and minimize the residual lesion, so as to achieve the optimal cytoreduction and improve the prognosis. As a feasible therapeutic regimen for the patients with primary unresectable AOC, neoadjuvant chemotherapy can improve the surgical condition and can increase the optimality of cytoreduction. It is important therefore to evaluate the feasibility of surgical treatment and make a proper selection of the primary treatment plan and neoadjuvant chemotherapy, so as to enhance the optimality of surgery and avoid an accident exploratory lapar otomy. At present, methods of feasibility evaluation for optimal cytoreduction of AOC are fol ows: 1) radiography, ie, CT, PET and MRI scanning; 2) CA-125 value; 3) laparoscopic exploration; 4) other tumor markers such as p53. Yet, any method lacks the ability to cover al the predicting factors influencing the outcome of cytoreduction, and to evaluate the surgery across the board. Searching for new methods and combining two or more procedures to evaluate the feasibility of cytoreduction may increase the optimality, reduce the residual focus, prolong survival time and improve the prognosis. In this study, recent advances in evaluation of the feasibility for optimal cytoreduction and the selection of neoadjuvant chemotherapeutic regimens were reviewed.
其他文献
输尿管阴道瘘多发生于妇产科手术所致的输尿管损伤后,可引起尿瘘、尿外渗、感染和肾功能损害.为提高对这一并发症的认识,降低其发生率,我们总结了我院妇产科1999年至2006年间收治的输尿管阴道瘘患者共5例的临床资料,并结合国内外文献,对其发生的原因、诊断及临床处理作一探讨。
出生缺陷(birth defect)是指先天性的严重偏离正常形态和功能的一系列临床病变.美国出生缺陷率约为3%[1],而我国目前共有先天性畸形患者3000多万人,每年大约有100万左右缺陷婴儿出生[2].在20世纪60年代以前,胎盘被认为是一个天然的屏障,任何的毒性物质都不能通过胎盘影响胎儿。
水中阴离子分析通常用化学分析法和离子选择电极法测定,耗时间长。1975年国外就有关于离子色谱测定水中阴离子的报道。文章强调离子色谱在快速、灵敏地测定阴离子的有效性。
目的 检测多囊卵巢综合征(PCOS)患者卵巢黄素化颗粒细胞胰岛素受体底物(IRS)-1、IRS-2蛋白表达及其酪氨酸磷酸化水平,探讨卵巢局部胰岛素抵抗的分子机制.方法收集行体外受精-胚胎移植治疗的11例PCOS患者(PCOS组)和15例排卵正常的输卵管性不孕患者(对照组)促排卵后卵巢黄素化颗粒细胞,采用放射免疫法检测血清LH、FSH、睾酮及空腹胰岛素(FINS)水平;采用葡萄糖氧化酶法测定空腹血糖
1月3日,中原油田基地第一幼儿园的小朋友们在老师地辅导下,画出了一幅幅美好祝愿的图画。这些带着新春问候的绘画作品将寄给孩子们远在国外工作的爸爸,祝福爸爸在新的一年里
人发中元素的测定,对研究人发中元素与身体健康的关系,确定正常值含量范围等方面有着重要的意义。电感耦合等离子体原子发射光谱分析(ICP-AES),具有准确、灵敏、干扰小、动
中国一拖集团有限公司河南省洛阳市涧西区建设路154号网址:www.yituo.com.cn电话:8008831801东方红LG-1404型轮式拖拉机,是大型四轮驱动农业动力机械,配套各种农具进行田间耕
本报讯记者余春瑜北京报道提起辽宁新风,业内都知道这是一家生产高压共轨系统的企业,提起德国康德瑞恩,知道的人可能就没那么多了。但是在电磁阀领域,康德瑞恩可是一家大名鼎
组织工程学(tissue engineering)是一门将细胞生物学和材料学相结合进行体外或体内构建组织或器官的新兴学科,是将少量种子细胞在体外扩增后种植于天然的或人工合成的细胞外基质上,经过一段时间的培养后,移植到体内,最终形成具有正常结构和功能的组织或器官,以达到替代修复病变和缺损的组织器官,重建解剖和生理功能[1-2]。
The deuterium depth distribution for a 20 keV/D D_3~+beam implanted into ytterbium(Yb) at a temperature between 300 and 340 K was studied using the D(d,p)T reac