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目的观察高压氧预处理对大鼠运动性疲劳的影响。方法将SD大鼠置于加压氧舱进行高压氧(压力250kPa,氧气浓度≥99%)预处理,以加压氧舱内常压空气通风处理作为对照,预处理后进行负重游泳实验。通过力竭时间及血清和骨骼肌乳酸、丙二醛、超氧化物歧化酶等指标的水平评估高压氧预处理对大鼠运动性疲劳的影响。结果高压氧预处理后大鼠负重游泳力竭时间为(56.13±16.91)min,较常压空气组[(23.13±9.85)min]延长(P<0.01)。负重游泳20min时,高压氧预处理组大鼠血清及骨骼肌中乳酸和丙二醛水平均较常压空气组降低(P<0.01),超氧化物歧化酶水平均较常压空气组升高(P<0.01)。结论高压氧预处理能够显著延缓大鼠运动性疲劳的产生。
Objective To observe the effect of hyperbaric oxygen preconditioning on exercise-induced fatigue in rats. Methods SD rats were placed in pressurized oxygen chamber for hyperbaric oxygen (pressure 250kPa, oxygen concentration ≥ 99%) pretreatment, to pressurize the atmospheric pressure air ventilation treatment as a control, after pretreatment load-bearing swimming experiment. The effect of hyperbaric oxygen preconditioning on exercise-induced fatigue in rats was evaluated by the time of exhaustion and the levels of serum lactate, malondialdehyde and superoxide dismutase in serum and skeletal muscle. Results After exhaustive exercise, hyperbaric oxygen preconditioning time was (56.13 ± 16.91) min in rats, which was prolonged (23.13 ± 9.85) min compared with that in normal air group (P <0.01). The levels of lactate and malondialdehyde in serum and skeletal muscle of hyperbaric oxygen preconditioning group were both lower than those of the normal-pressure air group (P <0.01) at 20-minute swimming load, and the level of superoxide dismutase was higher than that of the normal-pressure air group (P <0.01). Conclusion Hyperbaric oxygen preconditioning can significantly delay the occurrence of exercise-induced fatigue in rats.