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目的探讨兰索拉唑四联方案治疗幽门螺杆菌(Hp)阳性胃溃疡的临床疗效。方法采用随机数字表法将182例Hp感染的胃溃疡患者随机分为观察组和对照组,每组91例。观察组给予兰索拉唑+阿莫西林克拉维酸钾+克拉霉素+果胶铋治疗。对照组给予奥美拉唑+阿莫西林克拉维酸钾+克拉霉素治疗。疗程为期7d。疗程结束4周后复查Hp,比较Hp根除率、症状缓解率及不良反应情况。结果以兰索拉唑为基础的四联疗法治疗Hp感染,其Hp根除率和临床总有效率均明显高于传统奥美拉唑为基础的三联疗法,两组相比差异具有统计学意义(P<0.05)。治疗中患者不良反应较轻,仅少数患者出现头晕、恶心、腹泻症状,均可耐受,未影响治疗。结论以兰索拉唑为基础的四联方案治疗Hp感染阳性胃溃疡患者Hp根除率高,患者顺应性好,不良反应少,可在临床上推广应用。
Objective To investigate the clinical efficacy of lansoprazole quadruple regimen in the treatment of Helicobacter pylori (Hp) -positive gastric ulcer. Methods A total of 182 patients with gastric ulcer infected with Hp were randomly divided into observation group and control group with 91 cases in each group. The observation group was given lansoprazole + amoxicillin potassium clavulanate + clarithromycin + pectin bismuth treatment. The control group was given omeprazole + amoxicillin clavulanate potassium + clarithromycin. Course of 7d. Four weeks after the end of treatment review Hp, Hp eradication rate, symptom response rate and adverse reactions. Results Lansoprazole-based quadruple therapy for Hp infection showed that the Hp eradication rate and total clinical effective rate were significantly higher than those of traditional omeprazole-based triple therapy. The differences between the two groups were statistically significant ( P <0.05). Adverse reactions in patients with mild treatment, only a few patients with dizziness, nausea, diarrhea symptoms may be tolerated, did not affect the treatment. Conclusions Lansoprazole-based quadruple regimen in Hp infection-positive gastric ulcer patients with high Hp eradication rate, patients with good response, fewer adverse reactions, which can be widely applied in clinic.