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目的:探讨去整合素-金属蛋白酶17(ADAM17)在宫颈鳞状细胞癌中的表达及其临床病理意义。方法:运用免疫组织化学法分别检测正常宫颈上皮、宫颈鳞状细胞癌及宫颈上皮内瘤样变组织中ADAM17的表达,并分析其与宫颈癌临床分期及淋巴结转移的相关性。结果:ADAM17在正常宫颈上皮组织切片中无明显表达,在宫颈上皮内瘤样变组织中少部分表达,呈浅黄色,在宫颈鳞状细胞癌中癌细胞大量表达,ADAM17表达呈棕褐色,数量较多且浓染。不同临床分期的宫颈鳞状细胞癌组织中ADAM17的阳性表达率比较存在显著统计学差异(P<0.05),且随临床分期的上升,ADAM17的表达逐渐升高;有淋巴结转移的宫颈鳞状细胞癌组织中ADAM17的阳性表达率显著高于无淋巴结转移的宫颈鳞状细胞癌组织,差异具有统计学意义(P<0.05)。结论:ADAM17蛋白在宫颈鳞状细胞癌组织中呈异常高表达,且与宫颈鳞状细胞癌的临床分期和淋巴结转移密切相关,通过检测ADAM17蛋白的表达可能有助于宫颈鳞状细胞癌的诊断、治疗和预后预测。
Objective: To investigate the expression of integrin-metalloproteinase 17 (ADAM17) in cervical squamous cell carcinoma and its clinicopathological significance. Methods: The expression of ADAM17 in normal cervical squamous cell carcinoma, cervical squamous cell carcinoma and cervical intraepithelial neoplasia was detected by immunohistochemistry. The correlation between ADAM17 expression and clinical stage and lymph node metastasis was analyzed. Results: ADAM17 was not expressed in normal cervical epithelial tissue sections, but was expressed in a small amount in the cervical intraepithelial neoplasia. The expression of ADAM17 in the cervical squamous cell carcinoma was high, the expression of ADAM17 was tan, More and thick dye. The positive rates of ADAM17 expression in cervical squamous cell carcinoma with different clinical stages were significantly different (P <0.05), and the expression of ADAM17 was gradually increased with the increase of clinical stage; cervical squamous cell with lymph node metastasis The positive expression rate of ADAM17 in cancer tissues was significantly higher than that in cervical squamous cell carcinoma without lymph node metastasis, the difference was statistically significant (P <0.05). Conclusion: ADAM17 protein is highly expressed in cervical squamous cell carcinoma and closely related to the clinical stage and lymph node metastasis of cervical squamous cell carcinoma. It may be helpful to diagnose cervical squamous cell carcinoma by detecting the expression of ADAM17 protein , Treatment and prognosis prediction.