从1803年发现象牙化石含有氟以来,人们认识到在动物组织中存在氟,但对氟的生物学意义仍然是不清楚的。1903年在比利时首先发生了气体氟中毒,以后又发生无机和有机氟化物中毒,才引起人们对氟的毒性的重视;并证明了地方性氟异常(斑釉齿)的原因是饮水中氟过多。但在发现斑釉齿患者中龋齿少后,又采取了饮水氟化和在牙齿表面涂氟等措施预防龋齿。本文仅就氟的生物学作用,作一些简 Since the discovery of ivory fossil containing fluorine in 1803, it has been recognized that there is fluoride in animal tissues, but the biological significance of fluorine remains unclear. In 1903, the first occurrence of gas fluorosis in Belgium, followed by inorganic and organic fluoride poisoning, caused the people to attach importance to the toxicity of fluorine; and proved that the cause of endemic fluorine abnormalities (spot glaze teeth) many. However, after the discovery of less teeth in patients with spot glaze teeth, fluoridation of drinking water and fluoride on the tooth surface were adopted to prevent dental caries. This article only on the biological role of fluorine, make some Jane