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目的了解海南省慢性阻塞性肺疾病(COPD)患者螨类致敏原的分布特点,以及致敏性因素在COPD急性加重中的作用。方法选取2009年1月-6月65例COPD患者、58例非过敏性其他疾病患者及34名正常对照者行致敏原皮肤点刺试验(SPT),对结果进行分析,并对以上65例COPD患者进行为期3年的临床观察,分析SPT结果与急性加重次数的相关性。结果 COPD组螨类致敏原SPT阳性率与非致敏性其他疾病组及正常对照组差异均有统计学意义(P<0.05),且螨类致敏原中热带无爪螨SPT阳性率最高。而COPD患者SPT阳性组与阴性组急性加重次数差异无统计学意义(P>0.05)。结论 COPD的发生可能有外源性致敏原所致超敏反应因素的参与,对于海南省COPD患者,热带无爪螨可能是最重要的致敏原。但COPD急性加重与过敏并无明显相关性。
Objective To understand the distribution characteristics of mite allergens in patients with chronic obstructive pulmonary disease (COPD) in Hainan Province and the role of allergens in acute exacerbation of COPD. Methods 65 patients with COPD from January to June 2009, 58 patients with non-allergic diseases and 34 normal controls were selected for skin prick test (SPT), and the results were analyzed. The above 65 cases COPD patients for a 3-year clinical observation, analysis of SPT results and acute exacerbation of the correlation. Results The positive rates of SPT in mite allergens and non-hypersensitivity groups in COPD group were significantly different from those in normal controls (P <0.05), and the positive rate of SPT in mite allergens was the highest . There was no significant difference in the number of acute exacerbations between SPT positive group and negative group in COPD patients (P> 0.05). Conclusions The occurrence of COPD may be related to the hypersensitivity factors induced by exogenous allergens. For the COPD patients in Hainan Province, T. gonorrhoeae may be the most important allergen. However, acute exacerbation of COPD and no significant correlation between allergies.