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[目的]探讨不同血液净化方式对终末期肾病(ESRD)患者炎症因子及血尿素氮(BUN)、甲状旁腺激素(PTH)、β2微球蛋白(β2-MG)水平的影响.[方法]80例行维持性血透(MHD)患者分为常规血液透析(HD)组(A组)和HD+血液灌注(HP)组(B组),各40例.治疗6个月后比较两组炎症因子及相关指标变化.计算残余肾功能(RRF),测定BUN、C反应蛋白(CRP)、白介素-6(IL-6)、血浆同型半胱氨酸(Hcy)、PTH、β2-MG水平.[结果]治疗后两组RRF、BUN均下降,但B组RRF、BUN均高于A组,且差异有显著性(P＜0.05);B组透析后CRP、IL-6、Hcy、PTH、β2-MG均较透析前下降(P＜0.05),A组透析前后比较无明显变化,两组透析后比较差异有显著性(P＜0.05).[结论]与HD相比,HD+HP治疗ESRD患者可清除炎性因子及PTH、β2-MG,减轻对RRF的损害.“,”[Objective]To investigate the effects of two different blood purification methods on the levels of inflam-matory factors,blood urea nitrogen(BUN),parathyroid hormone(PTH)and β2-microglobulin(β2-MG)in patients with end-stage renal disease(ESRD).[Methods]A total of 80 cases of patients undergoing maintenance hemodialysis(MHD)were divided into two groups :group A with routine hemodialysis and group B with routine hemodialysis com-bined with hemoperfusion(HP),with 40 cases in each group.After 6 months of treatment,the residual renal function(RRF)was calculated.The levels of BUN,C reactive protein(CRP),interleukin-6(IL-6),plasma homocysteine(Hcy),PTH and β2-MG were determined.[Results]After hemodialysis,the value of RRF and BUN decreased in both groups ;however,RRF and BUN in group B were higher than those in group A(P ＜0.05).After hemodialysis,levels of CRP,IL-6,Hcy,PTH and β2-MG in group B were lower than those before hemodial4ysis(P ＜0.05),but these in-dices did not undergo much change after hemodialysis compared to before in group A.So,there were significant differ-ences between the two groups after hemodialysis(P ＜0.05).[Conclusion]Compared to routine hemodialysis,hemodial-ysis combined with hemoperfusion can clear inflammatory factors as well as PTH and β2-MG in patients with ESRD,and reduce the damage to RRF.