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自1975年Metcalf成功地从体外琼脂培养体系中培养了小鼠骨髓巨核细胞集落(CFU-M)以后,Nakeff在1976年也报告了CFU-M的培养方法,这些实验对研究巨核细胞的性质提供了良好的条件。在正常情况下,巨核细胞的数量少,它处于不断增殖分化又不断成熟的不稳定状态,建立巨核细胞体外培养方法,对研究其生理特性是很重要的,对研究各种细胞群之间的相互调控作用也是必要的。一、巨核细胞增殖分化模型
After Metcalf successfully cultured mouse bone marrow megakaryocyte colonies (CFU-M) from an in vitro agar culture system in 1975, Nakeff also reported on the CFU-M culture in 1976. These experiments provide the basis for investigating the properties of megakaryocytes Good condition. Under normal circumstances, the small number of megakaryocytes, it is in a constantly proliferating and continuously unstable state of maturation, the establishment of megakaryocyte in vitro culture method, to study its physiological characteristics is very important for the study of various cell populations The role of mutual regulation is also necessary. First, megakaryocyte proliferation and differentiation model