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木文对长春花(Catharanthus roseus Linn.G.Don)中分离提出的生物碱AC-875进行了毒性及抗癌作用的实验研究.试验结果表明AC-875在20-42毫克/公斤时,对小鼠Ehrlich腹水癌及腹水型肝癌均有明显的抑制作用.当剂量为10毫克/公斤时,对大鼠腹水型吉田肉瘤也有较好的疗效.在实体瘤的治疗中,注射35毫克/公斤,对小鼠S-180仅有轻度抑制作用,且不太稳定.对小鼠网织细胞瘤、Ehrlich腹水癌实体瘤、大鼠Jensen肉瘤及Walker癌等则无抑制作用.给小鼠腹腔注射AC-875的急性LD_(50)为170毫克/公斤,亚急性LD_(50)为61毫克/公斤.给大白鼠腹腔注射AC-875的意性及亚急性LD_(50)分别为122毫克/公斤及18毫克/公斤.给家兔静脉注射8毫克/公斤AC-875时,心电图无明显变化.静脉注射AC-875 1毫克/公斤、2.5毫克/公斤或皮下注射5毫克/公斤,对狗的肝、肾功能、尿常规、红血细胞、血红蛋白及体重均无明显影响,但2.5和5毫克/公斤组,狗的白细胞有下降现象.
Mu Wen on the catharanthus roseus (Catharanthus roseus Linn.G.Don) isolated alkaloid AC-875 toxicity and anti-cancer experimental study shows that AC-875 at 20-42 mg / kg, the Mouse Ehrlich ascites carcinoma and ascites hepatocellular carcinoma have a significant inhibitory effect.When the dose of 10 mg / kg, the rat ascites type Yoshida sarcoma also has a good effect in the treatment of solid tumors, the injection of 35 mg / kg , Only mild inhibitory effect on mouse S-180, and not too stable on mouse reticulomatosis, Ehrlich ascites solid tumor, rat Jensen sarcoma and Walker cancer, etc. no inhibition to the mouse abdominal cavity The acute LD 50 of AC-875 injected was 170 mg / kg and the subacute LD 50 was 61 mg / kg.The mean and subacute LD 50 values for AC-875 mice were 122 mg / Kg and 18 mg / kg. There was no significant change in electrocardiogram when intravenous injection of 8 mg / kg of AC-875 was given to rabbits and intravenous injection of AC-875 at 1 mg / kg, 2.5 mg / kg or subcutaneous injection at 5 mg / kg Dog liver, kidney function, urine routine, red blood cells, hemoglobin and body weight had no significant effect, but 2.5 and 5 milliseconds G / kg group, the dog’s white blood cells have decreased.