Glacier retreat is not only a symbol of temperature and precipitation change, but a dominating factor of glacial lake changes in alpine regions, which are of wide concern for high risk of potential outburst floods. Of all types of glacial lakes, moraine-dammed lakes may be the most dangerous to local residents in mountain regions. Thus, we monitored the dynamics of 12 moraine-dammed glacial lakes from 1974 to 2014 in the Poiqu River Basin of central west Himalayas, as well as their associated glaciers with a combination of remote sensing, topographic maps and digital elevation models(DEMs). Our results indicate that all monitored moraine-dammed glacial lakes have expanded by 7.46 km2 in total while the glaciers retreated by a total of 15.29 km2 correspondingly. Meteorological analysis indicates a warming and drying trend in the Nyalam region from 1974 to 2014, which accelerated glacier retreat and then augmented the supply of moraine-dammed glacial lakes from glacier melt. Lake volume and water depth changed from 1974 to 2014 which indicates that lakes Kangxico, Galongco, and Youmojanco have a high potential for outburst floods and in urgent need for continuous monitoring or artificial excavation to release water due to the quick increase in water depths and storage capacities. Lakes Jialongco and Cirenmaco, with outburst floods in 1981 and 2002, have a high potential risk for outburst floods because of rapid lake growth and steep slope gradients surrounding them. Glacier retreat is not only a symbol of temperature and precipitation change, but a dominating factor of glacial lake changes in alpine regions, which are of wide concern for high risk of potential outburst floods. Of all types of glacial lakes, moraine-dammed lakes may be the most dangerous to local residents in mountain regions. Thus, we monitored the dynamics of 12 moraine-dammed glacial lakes from 1974 to 2014 in the Poiqu River Basin of central west Himalayas, as well as their associated glaciers with a combination of remote sensing , topographic maps and digital elevation models (DEMs). Our results indicate that all monitored moraine-dammed glacial lakes have expanded by 7.46 km2 in total while the glaciers retreated by a total of 15.29 km2 correspondingly. Meteorological analysis indicates a warming and drying trend in the Nyalam region from 1974 to 2014, which accelerated glacier retreat and then augmented the supply of moraine-dammed glacial lakes from glacier melt. and water depth changed from 1974 to 2014 that indicates that Lakeskes Kangxico, Galongco, and Youmojanco have a high potential for outburst floods and in urgent need for continuous monitoring or artificial excavation to release water due to the quick increase in water depths and storage capacities. Lakes Jialongco and Cirenmaco, with outburst floods in 1981 and 2002, have a high potential risk for outburst floods because of rapid lake growth and steep slope gradients surrounding them.