论文部分内容阅读
目的探讨咽喉部人乳头状瘤病毒(HPV)感染与良、恶性肿瘤样病变的关系。方法采取25例声带息肉、24例咽喉鳞状上皮乳头状瘤和19例喉鳞状细胞癌临床活检石蜡组织标本,用流式荧光杂交技术检测HPV基因型19种高危亚型和7种低危亚型的表达。结果 HPV感染率在声带息肉组为24%(6/25),咽喉乳头状瘤组为37.5%(9/24),喉鳞癌组为10.5%(2/19)。良性病例HPV亚型感染以HPV6和HPV11亚型为主,鳞癌病例仅为HPV16亚型。结论咽喉部肿瘤样病变的发生与HPV感染密切相关,部分良性病例伴有HPV16亚型感染,可以作为提示恶变倾向的指征。
Objective To investigate the relationship between human papillomavirus (HPV) infection in throat and benign and malignant tumor-like lesions. Methods Twenty-five cases of vocal cord polyps, 24 cases of laryngeal squamous epithelial papilloma and 19 cases of laryngeal squamous cell carcinoma were included in the study. Ninety-seven high-risk subtypes of HPV genotype and seven low-risk subtypes were detected by flow cytometry Subtype expression. Results The prevalence of HPV infection was 24% (6/25) in vocal cord polyps, 37.5% (9/24) in throat papilloma and 10.5% (2/19) in laryngeal squamous cell carcinoma. The HPV subtypes of HPV6 and HPV11 were predominant in benign cases of HPV subtype, and the cases of squamous cell carcinoma were only HPV16 subtype. Conclusions The occurrence of tumor-like lesions in the throat is closely related to HPV infection. Some of the benign cases are associated with HPV16 subtype infection, which can be used as an indication of malignant transformation.