论文部分内容阅读
目的观察应用齐多呋啶(ZDV)单剂短程疗法对人类免疫缺陷病毒(HIV)母婴传播的阻断作用。方法博茨瓦纳玛琳娜公主医院所有HIV阳性孕妇,自妊娠34周开始口服ZDV,300mg,2次/d,直到分娩开始。分娩开始时口服ZDV300mg,接着每隔3h口服300mg直到婴儿娩出,最大剂量1500mg。不能口服者ZDV静脉给药,第1小时负荷量2mg/kg,接着按1mg/(kg.h)直到婴儿娩出。婴儿治疗,出生后8～10h开始口服ZDV混悬糖浆,按8mg/(kg.d),分2次每12h口服,服药到4周。婴儿出生后避免母乳喂养。结果至出生后第6周共检测335例婴儿PCR-HIVRNA,其中阳性22例,母-婴垂直传播率降至6.6%。结论ZDV可显著降低HIV母婴传播。
Objective To observe the blocking effect of Zidovudine (ZDV) single dose short-course therapy on the transmission of human immunodeficiency virus (HIV) from mother to infant. METHODS All HIV-positive pregnant women at Princess Margaret Hospital in Botswana received oral ZDV 300 mg twice daily from 34 weeks of gestation until the beginning of labor. ZDV oral dose of 300mg at the beginning of childbirth, followed by oral administration of 300mg every 3h until the baby was delivered, the maximum dose of 1500mg. Oral ZDV can not be administered orally, the first hour load 2mg / kg, followed by 1mg / (kg.h) until the baby delivered. Infant treatment, 8 ~ 10h after birth oral ZDV suspension syrup, according to 8mg / (kg.d), divided into 2 times every 12h oral administration to 4 weeks. Avoid breastfeeding after birth. Results A total of 335 infants PCR-HIVRNA were detected in the 6th week after birth, of which 22 were positive and the mother-infant vertical transmission rate was reduced to 6.6%. Conclusion ZDV can significantly reduce the mother-to-child transmission of HIV.