目的探讨比较阿立哌唑与利培酮治疗精神发育迟滞合并精神分裂症的疗效及安全性。方法将80例精神发育迟滞合并精神分裂症患者随机分为两组，分别使用阿立哌唑（治疗剂量15~30mg/d）和利培酮（治疗剂量4~6mg/d）进行为期20w的临床观察，采用PANSS减分率进行疗效评估。结果阿立哌唑组的治疗有效率为95%，利培酮组的治疗有效率为90%，差异无统计学意义（>0.05），但阿立哌唑组的不良反应发生率明显低于利培酮组。结论阿立哌唑和利培酮治疗精神发育迟滞合并精神分裂症的精神症状疗效均肯定，但阿立哌唑较利培酮治疗精神发育迟滞合并精神分裂症更安全，不良反应少。“,”Objective To compare the curative effect and safety of aripiprazole and risperidone in treating mental retardation (MR) complicated schizophrenia. Methods Eighty patients with mental retardation complicated with schizophrenia were randomly divided into aripiprazole treatment group and risperidone treatment group. The clinical observation was last for twenty weeks, and PANSS reduction ratio was used for efficacy evaluation. Results The effective rate of aripiprazole treatment group was 95%, which in risperidone group was 90%, The effectiveness was similar, but the adverse reaction of aripiprazole group was obviously lower than risperidone group. Conclusion Aripiprazole is a effective drug in treating retardation with schizophrenia, and it is more safer than risperidone due to less adverse reactions.