论文部分内容阅读
Sb-71用30毫克/公斤1次腹腔注射对小白鼠Ehrlich腹水瘤细胞的有丝核分裂有明显的抑制作用,时间持续达2年小时之久,以给药后6—12小时的作用最显著,各期分裂数普遍的减少,且对静止期细胞也有明显的影响(如染色质凝集和退变细胞增多等)。当以此药同剂量静脉注射时,其作用则明显减弱,仅于给药后1—3小时分裂指数略有下降,至6小时即恢复正常。用Sb-71同剂量作多次的腹腔注射,对瘤细胞的影响更为显著,此时95％以上的瘤细胞体积缩小,胞核凝缩浓染,看不到正常的分裂象,且腹水中瘤细胞浓度和总数也较对照组明显地减少。上述资料足以说明本药对Ehrlich腹水瘤的抑制作用,主要是由于它直接影响瘤细胞分裂繁殖的结果。
Sb-71 with 30 mg / kg intraperitoneal injection of mouse Ehrlich ascites tumor cells mitochondrial mitosis was significantly inhibited, the duration of up to 2 years, 6-12 hours after administration of the most significant role , The division of the number of the general decline, and the quiescent cells also have a significant impact (such as chromatin condensation and degeneration of cells, etc.). When the same dose of this drug intravenous injection, its role was significantly reduced, only 1-3 hours after administration of the mitotic index decreased slightly, to 6 hours to return to normal. With the same dose of Sb-71 intraperitoneal injection for many times, the impact on tumor cells is more pronounced, then more than 95% of the tumor cells shrink the size of condensed condensed nuclei, can not see the normal schizoid, and ascites Tumor cells in the total concentration and the number of significantly reduced compared with the control group. The above data sufficient to illustrate the drug on the inhibition of Ehrlich ascites tumor, mainly because it directly affects the results of tumor cell division.