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目的探寻一氧化碳(CO)中毒急性期的脑电图(EEG)对于发生迟发性脑病的预测价值。方法 102例急性CO中毒患者作为研究对象,均在入院时、治疗后以及出院时进行EEG检查,治疗后32例发生CO中毒迟发性脑病(DEACMP),设为观察组,70例未出现DEACMP症状,设为对照组。统计两组患者的EEG异常例数,并比较两组EEG情况。结果 102例患者在入院时均做EEG,其中有28例为中-重度异常,表现为背景慢波化,25例为轻度或边缘性异常,余49例为正常EEG。治疗35 d后观察,观察组中-重度异常EEG患者为27例,对照组为1例,观察组正常或轻度异常EEG患者为5例,对照组为69例,比较差异有统计学意义(P<0.01)。结论中-重度EEG异常的急性CO中毒患者更易发生DEACMP,其EEG表现与临床病程发展平行,早期监测EEG对预测迟发性脑病具有积极意义。
Objective To investigate the predictive value of EEG in the acute phase of carbon monoxide (CO) poisoning for the occurrence of delayed encephalopathy. Methods A total of 102 patients with acute CO poisoning were enrolled in this study. EEG examination was performed at admission, after treatment and at discharge. 32 patients with CO poisoning delayed encephalopathy (DEACMP) were treated as observation group and 70 patients did not have DEACMP Symptoms, as a control group. Statistics EEG abnormalities in two groups of patients, and compare the two groups of EEG. Results EEG was performed in 102 patients at admission, 28 of them were moderate to severe abnormalities. The results showed that the background was slow wave, 25 cases were mild or marginal abnormalities and the other 49 cases were normal EEG. After 35 days of treatment, 27 patients with moderate-severe abnormal EEG in the observation group and 1 patient in the control group showed that there were 5 cases with normal or mild abnormal EEG in observation group and 69 cases in control group with statistically significant difference P <0.01). Conclusions DEACMP is more likely to occur in acute CO poisoning patients with moderate-severe EEG abnormalities. The EEG manifestation is in parallel with the development of clinical course. Early monitoring of EEG is of positive significance in predicting delayed encephalopathy.