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为探讨运动性心肌肥大和高血压心肌肥大对缺血再灌注损伤的差异，本文在大鼠游泳训练心肌肥大和主动脉缩窄性高血压心肌肥大离体心脏灌流模型上，观察它们对缺血再灌注损伤的差异。结果表明，反映组织损伤程度的指标如乳酸脱氢酶漏出，心肌脂质过氧化终产物丙二醛（ＭＤＡ）和心肌钙在高血压心肌肥大的心肌较对照组和运动心肌肥大组皆明显升高，而运动组和对照组则无差异，高血压心肌肥大的程度和运动性心肌肥大的程度基本一致。本研究提示运动性心肌肥大的心肌抗缺血再灌注损伤的能力较高血压心肌肥大者增强。
In order to investigate the differences of myocardial hypertrophy and hypertensive myocardial hypertrophy on ischemia-reperfusion injury, we observed the effects of ischemia-reperfusion on myocardial perfusion in rats with myocardial hypertrophy and aortic constriction hypertrophy Reperfusion injury differences. The results showed that indicators reflecting the extent of tissue damage, such as the leakage of lactate dehydrogenase, myocardial lipid peroxidation products of malondialdehyde (MDA) and myocardial calcium in hypertensive myocardium hypertrophy myocardial compared with the control group and exercise myocardial hypertrophy group were significantly increased High, while there was no difference between exercise group and control group. The degree of hypertensive myocardial hypertrophy and exercise-induced myocardial hypertrophy were basically the same. This study suggests that exercise-induced hypertrophy of myocardium is more resistant to ischemia-reperfusion injury than hypertensive cardiac hypertrophy.