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目的:研究钩吻素子大鼠在体肠吸收动力学特征。方法:采用高效液相色谱法测定钩吻素子含量,以大鼠在体单向灌流法研究药物浓度、吸收部位和灌流液p H对钩吻素子肠吸收的影响。结果:小肠为钩吻素子主要吸收窗、十二指肠、空肠、回肠各段对钩吻素子的吸收无显著差异(P>0.05);钩吻素子吸收速率不受自身质量浓度影响,吸收机制符合被动扩散方式;钩吻素子在不同p H灌流液中吸收有显著性差异(P<0.05),碱性条件下钩吻素子吸收优于酸性条件。结论:钩吻素子在全肠段吸收良好,没有特定吸收窗口,提示该药物适合制成缓释制剂。
Objective: To study the kinetics of intestinal absorption of cynanchi kouin in rats. Methods: The content of koumissin was determined by high performance liquid chromatography (HPLC). The effects of drug concentration, absorption site and perfusate p H on the intestinal absorption of koumissin in rats were studied in vivo. Results: The small intestine was the main absorption window of koumissin. There was no significant difference in the absorption of koumin between duodenum, jejunum and ileum (P> 0.05). The absorption rate of koumissin was not affected by its own mass concentration, (P <0.05). Under alkaline conditions, hook kinin absorption was better than acidic conditions. CONCLUSION: Hook-ku element is well absorbed in the whole bowel and has no specific absorption window, suggesting that the drug is suitable for sustained-release preparation.