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以L-赖氨酸、乙二胺和端羧基聚乙二醇(PEG)为原料合成一种带聚乙二醇侧链的二元胺扩链剂(Lys-NH-PEG),然后以4,4’-二苯基甲烷二异氰酸酯(MDI)和Lys-NH-PEG为硬段,聚碳酸酯二醇(PCD)为软段,制备一种含端羧基聚乙二醇侧链的梳形聚氨酯.对所合成聚氨酯材料进行傅立叶变换红外光谱(FTIR)、氢核磁共振谱(1H-NMR)、凝胶渗透色谱(GPC)测试,测试结果表明得到了目标聚合物.该聚合物能在水中形成胶体,并能化学接枝白蛋白,表明所合成的聚氨酯的PEG侧链端羧基具有反应活性.这种具有可反应性的聚氨酯为进一步接枝生物分子以提高生物相容性提供了广阔的空间.
A diamine chain extender (Lys-NH-PEG) with polyethylene glycol side chain was synthesized from L-lysine, ethylenediamine and carboxyl terminated polyethylene glycol (PEG) , 4’-diphenylmethane diisocyanate (MDI) and Lys-NH-PEG as hard segments and polycarbonate diol (PCD) as soft segments to prepare a comb-shaped Polyurethanes The synthesized polyurethane materials were characterized by Fourier transform infrared spectroscopy (FTIR), hydrogen nuclear magnetic resonance (1H-NMR) and gel permeation chromatography (GPC) and the results showed that the target polymers were obtained. Form colloids, and chemically grafted albumin, indicating that the PEG side chain carboxyl groups of the synthesized polyurethane are reactive This reactive polyurethane provides a wide range of substrates for further grafting biomolecules for improved biocompatibility space.