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评价~3H 掺入哺乳动物(含人)细胞内的遗传和躯体效应的主要方法之一是估计经胎盘或经口掺入到胚胎或幼动物细胞内的~3H 所产生的生物学危害程度。无论是细胞增殖活动强的胚胎或幼动物还是断奶之后细胞增殖已显著减慢的年青动物,掺入到器官或组织中的~3H 都有很强的滞留,而且由于DNA 结合~3H,使~3H的滞留具有器官特异性,因而累积剂量也具有高度的器官特异性。欲知DNA 结合~3H 的剂量效应关系,需测定由DNA 结合~3H 在细胞内沉积所产生的核内
One of the major methods of assessing ~ 3H genetic and somatic effects incorporated into mammalian (human-containing) cells is to estimate the degree of biological hazard generated by ~ 3H incorporation into the embryonic or young animal cells via the placenta or orally. Whether it is an embryo or young animal with strong cell proliferation activity or a young animal whose cell proliferation has remarkably slowed down after weaning, ~ 3H incorporated into an organ or tissue has a strong retention, and because DNA binds ~ 3H, The retention of 3H is organ specific, so the cumulative dose also has a high degree of organ specificity. For DNA binding ~ 3H dose-response relationship, to be determined by DNA binding ~ 3H intracellular deposition of the resulting nucleus