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目的初步研究不同剂量百部新碱单体及百部新碱口腔崩解片对哮喘小鼠的治疗作用。方法将雌性BALB/C小鼠随机分成6组,每组6只,分别为正常对照组(control组)、模型组(model组)、阳性药物地塞米松组(DEX组)、百部新碱高剂量组(H组)、百部新碱低剂量组(L组)和百部新碱制剂组(Z组)。小鼠用卵清蛋白(OVA)腹腔注射致敏,并予2%OVA雾化吸入激发的方式建立哮喘小鼠模型,HE染色观察肺组织病理炎症变化,PAS染色观察肺组织杯状细胞增生情况。结果与正常对照组相比,模型组小鼠引喘潜伏期变短(P<0.01)、炎症评分增高(P<0.01)、杯状细胞增生明显(P<0.01);与模型组比较,百部新碱高低剂量组和制剂组小鼠引喘潜伏期变长(P<0.01),炎症评分降低(P<0.01)、杯状细胞增生减轻(P<0.01)。结论不同剂量百部新碱及百部新碱口腔崩解片均对小鼠哮喘有一定的治疗作用,且相同剂量百部新碱制剂的平喘效果强于百部新碱单体。
OBJECTIVE: To study the therapeutic effect of different doses of one hundred new base monomer and one hundred new alkali disintegrating tablets on asthmatic mice. Methods Female BALB / C mice were randomly divided into 6 groups with 6 mice in each group. The mice were divided into normal control group, model group, dexamethasone group, DEX group, High dose group (H group), 100 new alkali low dose group (L group) and 100 new base preparation group (Z group). The mice were sensitized intraperitoneally with ovalbumin (OVA) and challenged with 2% OVA inhalation. The mice model of asthma was established. The pathological changes of lung tissue were observed by HE staining. The goblet cell proliferation was observed by PAS staining . Results Compared with the normal control group, the latent period of asthma in model group was shorter (P <0.01), inflammation score was higher (P <0.01) and goblet cell hyperplasia was significantly (P <0.01). Compared with model group, Neonatal high and low dose groups and preparations of mice increased latency of asthma (P <0.01), inflammatory score decreased (P <0.01), goblet cell proliferation reduced (P <0.01). Conclusions Different doses of 100 new base alkali and 100 new oral base orally disintegrating tablet have a certain therapeutic effect on asthma in mice, and the same dose of new base preparation is superior to asthma more effective than one hundred base of new base monomer.