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作者报道了13例氟氯西林(flucloxacillin)治疗后发生胆汁郁积的肝活检组织学表现.大多数病例有黄疸及皮肤瘙痒.几乎所有病例在随访平均18个月后肝功能试验恢复正常.1例病人出现黄疸7个月后死亡,另1例临床证实为继发性胆汁性肝硬变.组织活检典型的表现为肝细胞和小管胆汁郁积,伴轻微或无肝炎.通常有轻度门静脉纤维化和门脉区斑状淋巴细胞浸润.4例病人肝管数目减少,6例胆管变小.胆管上皮细胞显示退行性变化,偶见炎性细胞浸润.胆管增生有很大差异.有些病例,大多为严重病例即使胆汁排空,难以觉察.结果表明,其损害不仅是肝细
The authors reported the histological findings of liver biopsy of cholestasis after thirteen flucloxacillin treatments, with jaundice and pruritus in most cases.All the patients returned to normal liver function tests after an average follow-up of 18 months.1 case The patient died of jaundice after 7 months, and the other 1 case was clinically confirmed as secondary biliary cirrhosis. Tissue biopsy typically showed hepatocellular and ductal cholestasis with mild or no hepatitis, with mild portal fibrosis And portal area of the macular infiltration of lymphocytes .4 patients with reduced number of hepatic duct, 6 cases of bile duct smaller bile duct epithelial cells showed degenerative changes, occasionally inflammatory cell infiltration .Bile duct hyperplasia are very different in some cases, mostly Serious cases even if bile emptying, difficult to detect. The results show that the damage is not only liver fine