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目的:分析后代脑发育与母亲妊娠期甲状腺自身免疫功能异常之间相关性及影响因素。方法:通过对门诊753名孕妇进行了甲状腺功能筛查,确立TPO-Ab阳性而甲功正常者51例,在同一队列中设立阴性对照60例。对研究对象的子代在6个月龄进行脑功能发育评估,并对可能的影响因素进行分析。结果:与对照组比较,单纯TPO-Ab阳性组后代脑发育评分降低6分,具体表现在精细运动、社交行为和语言能力发育方面。TPO-Ab的状态和母亲的受教育程度影响婴儿脑功能发育,OR值分别为5.7和2.1。结论:甲状腺自身免疫功能异常可以影响后代的智力发育、特别是在精细运动、社交行为和语言方面能力的下降。
Objective: To analyze the correlation between the brain development of offspring and thyroid autoimmune dysfunction during pregnancy and its influencing factors. Methods: Thyroid function screening was conducted in 753 pregnant women in outpatient setting, 51 patients with positive TPO-Ab and normal thyroid function were established, and 60 negative controls were established in the same cohort. The offspring of the subjects were evaluated for brain development at 6 months of age, and the possible influencing factors were analyzed. Results: Compared with the control group, the score of brain development in offspring of TPO-Ab positive group decreased by 6 points, especially in fine motor, social behavior and language ability development. The status of TPO-Ab and maternal education affected the development of brain function in infants with odds ratios of 5.7 and 2.1, respectively. CONCLUSION: Abnormal thyroid autoimmune function can affect the intellectual development of offspring, especially in the fine motor, social behavior and language ability decline.