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目的：观察左旋肉碱对慢性肾功能衰竭腹透患者红细胞免疫功能的影响。方法：维持性腹透患者２３例，随机分为治疗组（１４例）和对照组（９例）。治疗组口服左旋肉碱１．０ｇ，２次／ｄ，疗程３个月；对照组口服等量生理盐水。结果：治疗组红细胞数量和血红蛋白含量无明显变化，但红细胞Ｃ３ｂ受体花环率、肿瘤细胞花环率均明显升高（Ｐ＜０．０５），血中氧化型低密度脂蛋白显著下降（Ｐ＜０．０５）。结论：口服左旋肉碱可改善慢性肾功能衰竭腹透患者的红细胞免疫功能低下状况。
Objective: To observe the effects of L-carnitine on erythrocyte immune function in patients with peritoneal dialysis of chronic renal failure. Methods: Twenty-three patients with peritoneal dialysis were randomly divided into treatment group (n = 14) and control group (n = 9). The treatment group oral L-carnitine 1.0g, 2 times / d, course of treatment for 3 months; the control group oral administration of the same amount of saline. Results: The number of erythrocytes and hemoglobin in the treatment group had no significant changes, but the rosette rate of C3b receptor and the rate of rosette of tumor cells were significantly increased (P <0.05), and the levels of oxidized low density lipoprotein in blood decreased significantly (P < 0.05). Conclusion: Oral administration of L-carnitine can improve erythrocyte immune dysfunction in patients with peritoneal dialysis of chronic renal failure.