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目的探讨人工流产妇女体内炎症介质白细胞介素-8(IL-8)水平变化的临床意义。方法术前查阴道分泌物IL-8水平,并行下生殖道感染的检测,以其中一种或以上微生物感染的孕妇200例作为观察组;对照组200例则无以上微生物感染,比较两组术前及用抗生素治疗后IL-8水平变化。结果观察组治疗前IL-8水平明显高于对照组,两组比较有显著性差异(P<0.05);观察组治疗前后IL-8水平呈明显下降,比较差异有显著性意义(P<0.05);而对照组用药前后IL-8水平无明显变化,比较无显著性差异(P>0.05)。结论IL-8可作为人工流产妇女感染的监测指标,当白细胞介素-8(IL-8)水平增高≥174.38ng/L时,人工流产妇女术前应常规行生殖道感染的筛查,为合理处理人工流产、合理使用抗菌素提供科学依据。
Objective To investigate the clinical significance of interleukin-8 (IL-8), an inflammatory mediator, in induced abortion women. Methods Preoperative vaginal discharge IL-8 levels, parallel detection of lower genital tract infection in which one or more of the 200 pregnant women infected with microorganisms as the observation group; 200 cases of the control group without the above microbial infection, the two groups were compared IL-8 levels before and after treatment with antibiotics. Results The level of IL-8 in the observation group before treatment was significantly higher than that in the control group, with significant difference between the two groups (P <0.05). The level of IL-8 in the observation group was significantly decreased before and after treatment, with significant difference (P <0.05 ), While there was no significant difference in IL-8 level before and after treatment in the control group (P> 0.05). Conclusion IL-8 can be used as a monitoring indicator for women with induced abortion. When the level of IL-8 is increased by 174.48ng / L, artificial abortion should be routinely performed for screening of genital tract infection before Reasonable treatment of induced abortion, rational use of antibiotics provide a scientific basis.